E4 Comfort

About the Study

The E4Comfort Study is evaluating an oral study medication to see if it may reduce hot flashes and night sweats in post-menopausal women. Estetrol, the study medication, is a synthetic form of the naturally occurring estrogen. It has shown in early testing to have minimal side effects. 

How Can I Qualify?

You may be able to participate if you:

  • Are a post-menopausal woman aged 40-65 years
  • Experience moderate-to-severe hot flushes
  • Started menopause within the last 10 years
  • Do not have a history of cancer, diabetes, or heart disease

Additional requirements will apply. The study staff can provide more details.

Participation in this study is completely voluntary, and you may withdraw from the study at any time.

Why Participate?

  • All study-related care will be provided at no cost

  • The study staff will closely monitor you, your symptoms and your overall health

  • You will be helping to advance knowledge of women’s health

Find A Study Site

The information you provide will be kept confidential.

About Hot Flushes and Night Sweats

Hot flushes and night sweats can be uncomfortable and disruptive. They are, however, a real medical condition that can be treated. If you have moderate-to-severe hot flushes, consider participating in a research study.


A hot flush is a sudden sensation of heat in the face, neck, chest, or all over that may cause you to become flushed and sweat heavily. Hot flushes that happen at night are called night sweats. Up to 80% of women experience hot flushes during menopause.

Hot flushes may be caused by fewer hormones, such as oestrogen and progesterone, being produced during menopause. These changes in hormone levels can affect your body’s temperature control system.


Find A Study Site

The information you provide will be kept confidential.

Frequently Asked Questions

About Clinical Research Studies

About the E4Comfort Study

Study Medication

Privacy, Stopping Participation, Costs and Permission

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